Imaging under liquid conditions is an important aspect of an atomic force microscope (AFM) to map the topography as well as mechanical properties of sample surface. Generally, the setup of AFM imaging under liquid conditions seem to be tricky due realigning the laser on the cantilever in liquid environment due to the refractive index change. However, Park Systems setup eases this process. Using liquid imaging one can easily map various samples including organic and biological cells as well. This webinar will focus on the basic principle and setup to map samples under liquid conditions.